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CAS No.: 937263-43-9
Synonyms: Irbinitinib;ARRY-380;ONT-380
Irbinitinib is a potent and selective HER2 inhibitor with IC50 of 8 nM, equipotent against truncated p95-HER2, 500-fold selective for HER2 versus EGFR.
生物活性
靶点 | HER2 (p95) IC50:8nM | HER2 IC50:8nM |
动物研究 | |
剂量 | Mice[2] (p.o.): 50 mg/kg - 200 mg/kg |
给药途径 | p.o. |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT01042379 | Breast Neoplasms ... more >> Breast Cancer Breast Tumors Collapse << | Phase 2 | Recruiting | - | - |
NCT03424473 | - | - | - | - | - |
NCT03722823 | Hepatic Impairment | Phase 1 | Recruiting | May 2019 | United States, California ... more >> Orange County Research Center Recruiting Tustin, California, United States, 92780 Contact: Rebecca Lopez rebecca.lopez@ocresearchcenter.com Principal Investigator: Joel Neutel United States, Florida Orlando Clinical Research Center Recruiting Orlando, Florida, United States, 32809 Contact: Jennie Jimenez jjimenez@ocrc.net Principal Investigator: Thomas Marbury United States, Tennessee NOCCR Knoxville and Volunteer Research Group Recruiting Knoxville, Tennessee, United States, 37920 Contact: Ben Brooks ben.brooks@amrllc.com Principal Investigator: William Smith United States, Texas Texas Liver Institute Recruiting San Antonio, Texas, United States, 78215 Contact: Mary Lou Hernandez mhernandez@txliver.com Principal Investigator: Eric Lawitz Collapse << |
实验方案
技术信息
CAS号 | 937263-43-9 | 储存条件 |
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分子式 | C26H24N8O2 | 运输 | 蓝冰 | |||||
分子量 | 480.52 | 别名 | Irbinitinib;ARRY-380;ONT-380;ONT-380. Irbinitinib | |||||
溶解度 |
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动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT01042379 | Breast Neoplasms ... more >> Breast Cancer Breast Tumors Collapse << | Phase 2 | Recruiting | - | - |
NCT03424473 | - | - | - | - | - |
NCT03722823 | Hepatic Impairment | Phase 1 | Recruiting | May 2019 | United States, California ... more >> Orange County Research Center Recruiting Tustin, California, United States, 92780 Contact: Rebecca Lopez rebecca.lopez@ocresearchcenter.com Principal Investigator: Joel Neutel United States, Florida Orlando Clinical Research Center Recruiting Orlando, Florida, United States, 32809 Contact: Jennie Jimenez jjimenez@ocrc.net Principal Investigator: Thomas Marbury United States, Tennessee NOCCR Knoxville and Volunteer Research Group Recruiting Knoxville, Tennessee, United States, 37920 Contact: Ben Brooks ben.brooks@amrllc.com Principal Investigator: William Smith United States, Texas Texas Liver Institute Recruiting San Antonio, Texas, United States, 78215 Contact: Mary Lou Hernandez mhernandez@txliver.com Principal Investigator: Eric Lawitz Collapse << |
NCT03777761 | Healthy | Phase 1 | Not yet recruiting | March 2019 | United States, Texas ... more >> Covance Clinical Research Unit Not yet recruiting Dallas, Texas, United States, 75247 Principal Investigator: Jennifer Zon, MD Collapse << |
NCT02614794 | HER2 Positive Breast Cancer | Phase 2 | Recruiting | July 2021 | - |
NCT03043313 | Colorectal Adenocarcinoma ... more >> ERBB2 Gene Amplification HER2/Neu Positive KRAS wt Allele NRAS wt Allele Recurrent Colorectal Carcinoma Stage III Colorectal Cancer AJCC v7 Stage IIIA Colorectal Cancer AJCC v7 Stage IIIB Colorectal Cancer AJCC v7 Stage IIIC Colorectal Cancer AJCC v7 Stage IV Colorectal Cancer AJCC v7 Stage IVA Colorectal Cancer AJCC v7 Stage IVB Colorectal Cancer AJCC v7 Collapse << | Phase 2 | Recruiting | June 30, 2019 | United States, Arizona ... more >> Mayo Clinic Hospital Recruiting Phoenix, Arizona, United States, 85054 Contact: Clinical Trials Referrals Office 855-776-0015 Principal Investigator: Tanios S. Bekaii-Saab Mayo Clinic in Arizona Recruiting Scottsdale, Arizona, United States, 85259 Contact: Clinical Trials Referrals Office 855-776-0015 Principal Investigator: Tanios S. Bekaii-Saab United States, Georgia Emory University Hospital/Winship Cancer Institute Recruiting Atlanta, Georgia, United States, 30322 Contact: Meredith Renfroe 404-778-2670 meredith.ann.renfroe@emory.edu Principal Investigator: Christina S. Wu United States, Massachusetts Dana-Farber Cancer Institute Recruiting Boston, Massachusetts, United States, 02215 Contact: Christopher Graham 617-632-5960 Christopher_Graham@DFCI.harvard.edu Principal Investigator: Kimmie Ng United States, Minnesota Mayo Clinic Recruiting Rochester, Minnesota, United States, 55905 Contact: Clinical Trials Referrals Office 855-776-0015 Principal Investigator: Joleen M. Hubbard United States, New York Roswell Park Cancer Institute Recruiting Buffalo, New York, United States, 14263 Contact: Karen A. Hicks 716-845-8947 karen.hicks@roswellpark.org Principal Investigator: Patrick M. Boland Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Derek Alexander 646-888-1381 alexandd@mskcc.org Principal Investigator: Andrea Cercek United States, North Carolina Duke University Medical Center Recruiting Durham, North Carolina, United States, 27710 Contact: Ireka Burrus 919-668-1861 Ireka.burrus@duke.edu Principal Investigator: John H. Strickler United States, Wisconsin Aurora Cancer Care-Milwaukee West Recruiting Wauwatosa, Wisconsin, United States, 53226 Contact: Jennifer Mathieu 414-302-2312 jennifer.mathieu@aurora.org Principal Investigator: Federico Augusto H. Sanchez Collapse << |
NCT03723395 | Drug-drug Interaction | Phase 1 | Recruiting | November 2018 | United States, Florida ... more >> Covance Clinical Research Unit Recruiting Daytona Beach, Florida, United States, 32117 Contact: Michelle Saint Pierre 386-366-6428 michelle.saintpierre@covance.com Principal Investigator: Hugh Coleman United States, Texas Covance Clinical Research Unit Recruiting Dallas, Texas, United States, 75247 Contact: Iona Tihina 469-513-6716 Ioana.Tihina@covance.com Principal Investigator: Jennifer Zon Collapse << |
NCT01983501 | HER2 Positive Breast Cancers | Phase 1 | Active, not recruiting | July 2019 | United States, Alabama ... more >> University of Alabama Birmingham, Alabama, United States, 35294 United States, Colorado University of Colorado Cancer Center Aurora, Colorado, United States, 80045 United States, Kansas University of Kansas Kansas City, Kansas, United States, 66160 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Oregon Providence Cancer Center Portland, Oregon, United States, 97213 United States, Tennessee Sarah Cannon Research Institute Nashville, Tennessee, United States, 37203 United States, Washington Northwest Medical Specialties Tacoma, Washington, United States, 98045 Canada, Ontario London Health Sciences Centre London, Ontario, Canada, N6A 5W9 Princess Margaret Cancer Centre Toronto, Ontario, Canada, M5T 2M9 Canada, Quebec Hospital de la Cite-de-la-Sante Laval, Quebec, Canada, H7M 3L9 Jewish General Hospital Montreal, Quebec, Canada, H3T 1E2 Collapse << |
NCT03501979 | Metastatic Breast Cancer ... more >> Leptomeningeal Disease Collapse << | Phase 2 | Not yet recruiting | September 2023 | United States, Alabama ... more >> University of Alabama at Birmingham Not yet recruiting Birmingham, Alabama, United States, 35294 Contact: Erica M Stringer-Reasor, MD 205-975-2816 esreasor@uabmc.edu United States, Texas University of Texas MD Anderson Cancer Center Not yet recruiting Houston, Texas, United States, 77030 Contact: Rashmi K Murthy, MD, MBE rmurthy1@mdanderson.org Collapse << |
NCT03054363 | Breast Cancer | Phase 1 Phase 2 | Recruiting | October 2020 | United States, Arizona ... more >> University of Arizona Recruiting Tucson, Arizona, United States, 85724 Contact: Dana Lewallen 520-626-2175 DLewallen@uacc.arizona.edu Principal Investigator: Pavani Chalasani United States, Colorado University of Colorado Denver Recruiting Aurora, Colorado, United States, 80045 Contact: Tiffany Colvin 720-848-0664 tiffany.colvin@ucdenver.edu Principal Investigator: Elena Shagisultanova, MD, PhD United States, Illinois Northwestern University Recruiting Chicago, Illinois, United States, 60611 Contact: Peggy Gilbertsen 312-695-1102 cancertrials@northwestern.edu Principal Investigator: William Gradishar United States, New Mexico New Mexico Cancer Care Alliance Recruiting Albuquerque, New Mexico, United States, 87131 Contact: Karwyn Gustafson 505-925-0380 KSGustafson@salud.unm.edu Principal Investigator: Ursa Brown-Glaberman United States, New York Stony Brook University Recruiting Stony Brook, New York, United States, 11794 Contact: Pushpa Talanki 631-638-0815 Pushpa.talanki@stonybrookmedicine.edu Principal Investigator: Alison Stopeck United States, Texas University of Texas Health Science Center San Antonio Recruiting San Antonio, Texas, United States, 78229 Contact: CTRC 210-450-5798 CTRCReferral@uthscsa.edu Principal Investigator: Andrew Brenner Collapse << |
NCT02025192 | HER2 Positive Metastatic Breas... more >>t Cancers Collapse << | Phase 1 | Active, not recruiting | July 2019 | United States, Colorado ... more >> University of Colorado Aurora, Colorado, United States, 80045 United States, Oregon Providence Cancer Center Portland, Oregon, United States, 97213 United States, Tennessee Sarah Cannon Research Institute Nashville, Tennessee, United States, 37203 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 United States, Washington Northwest Medical Specialties Tacoma, Washington, United States, 98405 Collapse << |
NCT03758339 | Healthy | Phase 1 | Completed | - | United States, Wisconsin ... more >> Covance Clinical Research Unit Madison, Wisconsin, United States, 53704 Collapse << |
靶点 | Description | IC50 |
---|---|---|
HER2 (p95) | IC50:8nM | |
HER2 | IC50:8nM |
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